Rapid screening method for veterinary drug multi-residue LC-MS/MS in milk

Michael S. Y oung and Kim Van Tran

Waters Corporation (Milford, MA, USA)

Application advantage

â– Fast, simple sample preparation for efficient multi-class/multi-residue analysis

â– Removal of potential phospholipid interferences from prepared samples

â– Fast and sensitive UPLCÂ®-MS/MS analysis

Waters Solutions

ACQUITY UPLCÂ®

XevoÂ® TQ MS

CORTECSÂ® UPLC 1.6 Î¼m column

Ostro? Sample Preparation Board

Key words

Milk, UPLC-MS/MS, veterinary drugs, phospholipids

Introduction

The Ostro sample preparation plate enables simple, rapid LC-MS determination of basic drugs and related compounds in biological samples. The Ostro sample plate facilitates liquid-liquid extraction, protein precipitation, filtration, and subsequent removal of phospholipids from the final extract. In this paper, the Ostro sample plate was used to screen the veterinary drug residues in milk. The use of this sample plate can effectively precipitate proteins and remove potentially interfering substances in a few simple steps to complete the preparation of the milk sample. As the extracted sample passes through the sample plate, the protein is removed by filtration and the phospholipid interference is removed by being retained on the patented adsorbent. After completing the simple sample preparation step, the reconstituted sample was analyzed using UPLC-MS/MS. To demonstrate the applicability of this method, we selected representative compounds from the major veterinary drug classes, including tetracycline, fluoroquinolone, sulfonamides, macrolides, beta-lactams, and beta-adrenergic drugs.

Milk veterinary drug multi-residue LC-MSMS rapid screening method.pdf

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