Wuhan University's innovative "targeted gene radiotherapy" theoretical results lead the world

China Education Equipment Purchasing News: According to a report by Science and Technology Daily correspondent Gao Xiang Gao Wei reporter Zhao Fenghua on May 26, Professor Zhou Yunfeng of the Oncology Department of Central South Hospital of Wuhan University explored a targeted chimeric startup subsystem. Has passed the appraisal of scientific and technological achievements in Hubei Province, reaching the international advanced level.

Since 2001, the academic team led by Zhou Yunfeng has devoted himself to the research of cancer gene radiotherapy, innovatively proposed the theory of "targeted gene radiotherapy" and explored a targeted chimeric promoter based on telomerase The system proves that the system can effectively regulate and enhance the specific expression of therapeutic genes in tumor cells under the action of radiation. The combined application with immune genes has a significant synergistic anti-tumor effect and provides a new target for tumor therapy Treatment strategy. That is, the discovery of this system will pinpoint the "target" for tumor gene radiotherapy.

Tumor gene radiation therapy is a new method of anti-tumor therapy with good prospects developed in recent years. This method is a combination of radiation therapy and gene therapy for tumor therapy. Inducing the expression of therapeutic genes while performing local radiotherapy on the tumor, radiation and genes form a joint killing on the tumor. One of the difficulties faced by this method is the lack of effective methods to limit the expression of therapeutic genes to tumor tissues, thereby effectively protecting normal tissues.

Professor Zhou Yunfeng's project has declared 3 invention patents, 2 of which have been authorized.

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