Japanese study found a protein that can delay the development of gradual freezing

A research team led by Professor Yingying Zhang from the Gifu Pharmaceutical University in Japan reported on the 13th online version of the British "Science Report" magazine that they found a protein that can delay the development of gradual freezing. This discovery is expected to contribute to clarify the pathogenesis of the disease and develop new therapeutic drugs.

Amyotrophic lateral sclerosis, commonly known as gradual freezing, is a disorder of the motor nerves in patients with this disease, which causes the body muscles to gradually become weak. About 10% of patients with gradual freezing disease are inherited diseases. As the detailed cause of the disease is not clear, the medical community has not found a cure for the disease.

When the research team compared the experimental rat with normal disease and normal mice, it was found that the "membrane penetrating glycoprotein nmb" (GPNMB) in experimental rats had a great relationship with the development of the disease.

The researchers used gene manipulation to enable the expression of GPNMB in dozens of experimental rats with frostbite. They found that the onset time of the former was delayed and the survival time was extended by 1 to 2 compared with the experimental rats About weeks, converted to humans, is equivalent to a life extension of about 10 months, thus confirming that GPNMB can delay the development of gradual freezing.

Researchers from Nagoya University Graduate School, Niigata University and other institutions also participated in the study.

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